Scientists have made significant progress in the effort to develop artificial kidneys for both mice and humans. In a breakthrough study, researchers combined the kidney’s filtration components with urine-concentrating structures to create advanced organoids—the most mature and complex kidney-like structures ever developed in a laboratory setting.
In their publication, the research team described how they generated kidney organoids that are far more sophisticated and functional than any previously grown in vitro. The study was conducted by a team led by the University of Southern California (USC) and published in Cell Stem Cell on September 17. The findings were also highlighted by EurekAlert.
Dr. Zhongwei Li, associate professor of medicine, stem cell biology, and regenerative medicine at USC’s Keck School of Medicine, explained:
“This represents a revolutionary tool for creating more accurate models to study kidney diseases, which affect one in seven adults worldwide.”
Li emphasized that the achievement marks an important milestone in the long-term goal of developing fully functional artificial kidneys—an advance that could one day offer hope to more than 100,000 patients in the United States currently awaiting kidney transplants, the only available treatment for end-stage renal disease.
Previously, Dr. Li’s laboratory had succeeded in building organoids composed of nephrons—the kidney’s filtration units—as well as structures resembling collecting ducts, which concentrate urine. In this latest step forward, the team refined the growth conditions for both mouse and human collecting duct cells in the laboratory.
They then implanted these cells into living mice, where the organoids matured further, expanded in size, and developed supporting connective tissues and blood vessels.
Remarkably, both the mouse and human organoid cells began to exhibit kidney-like functions: filtering blood, reabsorbing proteins such as albumin, secreting kidney hormones, and showing early signs of urine production.
This research does not yet mean that patients will soon receive fully artificial kidneys. However, it represents one of the most promising advances in regenerative medicine and nephrology. Creating organoids with both filtration and urine-concentrating abilities brings science a crucial step closer to building bioengineered kidneys that could one day replace the need for donor organs.
For now, these organoids provide researchers with powerful new models to study kidney diseases, test potential therapies, and better understand the mechanisms of renal failure. Ultimately, such innovations may pave the way for lab-grown, transplantable kidneys—a development that could transform the lives of millions worldwide.
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